As he prepares for another checkpoint called a "lion's den," Mr. Girard's main frustration is time.
A company called NewLink Genetics is working on a small-molecule inhibitor of another immune checkpoint called IDO.
Earlier this year, Curis partnered with India-based Aurigene to develop several drugs, including one with a similar mechanism of action to Keytruda (pembrolizumab) and Opdivo (nivolumab), which inhibit an immune-restricting "checkpoint" called PD-1.
We waited eight hours at a checkpoint called Zaatara just to get to a city one hour away.
Once a cell passes a checkpoint called the 'restriction point' at the end of the G1 phase, it is committed to dividing.
First, they tested the simplest possible model for the spindle assembly checkpoint, called 'direct inhibition' whereby Cdc20 molecules are inhibited by recruitment to the unattached kinetochore (Acquaviva et al, 2004) and activated constitutively in the cytoplasm.
Lack of energy can also halt your progress in a more irritating way, as it's needed to create checkpoints called soul links.
So migrants enter the country either by crossing the border between established border checkpoints — an illegal crossing — or by showing up at one of those checkpoints, called a port of entry.
Whenever it mingles with bytes that started their journey in the computers of another datacentre, it has to pass through checkpoints, called firewalls, that check its identification documents against a list of viruses and worms and other nasty bytes, roughly as the Israeli army might examine a Palestinian entering from the Gaza strip.
When it became clear that Kabul was ignoring their pleas, Ali added, an ALP commander he identified only as Mohammad, who oversaw three of the checkpoints, called his two bodyguards into battle with him.
