Sentence examples for checkpoint and progress from inspiring English sources

Rare cells that stochastically lose p53 or Rb function bypass this senescence checkpoint and progress towards cancer.

The ability of carcinogens to induce cells to evade the G1 DNA-damage checkpoint and progress into S-phase is known as the stealth property.

p53-defective cells fail to maintain the DNA damage-induced arrest, and gradually escape the checkpoint and progress into the M phase, when they eventually undergo aberrant mitoses (Bunz et al, 1998).

Although accumulation at G2/ prophase would enable cells to check their DNA damage and respond, the progression to metaphase and anaphase is disconcerting and suggests that these cells can escape from proper checkpoint control and progress through mitosis whilst still carrying unrepaired DSBs.

At 24 36 h, XL888 concentrations >40 nM resulted in an increase in G1 accompanied by a dramatic decrease in S. In these G1-class cells, the transition from G2+M accumulation at 12 h to G1 accumulation at 24 h indicates that a portion of the G2+M population was likely released from G2/M checkpoint surveillance and progressed to G1 and/or 4N-pseudo-G1 (via mitotic checkpoint slippage).

Since the products of HPGI genes are involved in checkpoint controls of the cell cycle, we reasoned that the faster cycle time in the heterozygotes could be the result of cells skipping a compromised checkpoint and therefore progressing faster through that phase of the cycle.

If patients with such tumors are treated with an inhibitor of cdk2 to trigger a G1 checkpoint response, even in the absence of DNA damage, normal RB+ cells will arrest at the G1 checkpoint and transformed RB- cells will progress into S phase.

The pace of the handover to Afghan forces is quickening, with checkpoints and patrol bases being handed over rapidly, and progress in Nad Ali scrutinised closely as a model for elsewhere.

Multipolar mitosis also leads to erroneous microtubule-kinetochore attachment, and cells with a weakened mitotic checkpoint can progress to anaphase even with abnormal attachments.

Competence and progress count.

And progress is necessary.