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As a result of all this reality checking, trials are getting longer and more cases that might previously have resulted in quick convictions are now ending in acquittals.Criminals watch television too, and there is evidence they are also changing their behaviour.
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Following database searches, we identified 116 individual citations, and a further 40 potential studies after we checked trial abstracts.
Will Tregoning, the founder of Unharm, an organisation aimed at changing Australia's prohibitionist drug policy, is a key player backing the drug checking trial.
The VIP differs from the health check trials cited in these evaluations in that it is individually and population-oriented.
Babalwa Zani (BZ) and Michael Gathu (MG) independently reviewed the results of the literature search, obtained full-text copies of all potentially relevant trials and checked each trial report for evidence of multiple publications from the same data set.
We checked that trials with multiple publications were managed as one trial.
As can be seen from graphs, measurements were replicated to check repeatability (trials I-III).
To compare voltage and calcium measurements, we routinely checked individual trials for consistency and averaged several recordings to improve the signal-to-noise ratio.
If we include any cluster-RCTs in future editions, we will check that trials have correctly adjusted for clustering and, if not, attempt to make this adjustment.
In order to prevent contaminations of MEPs by background EMG activity, a window of 100 ms before TMS pulse was used to check for trials with any background activity greater than 100 μV.
We excluded trials that were aiming for the registration of a new indication (i.e., phase IIIB trials) by checking the aim of the trials stated in the article and by double-checking in the public domain via FDA and EMA websites.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com