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This study is the first to show such long-lasting effects of quinpirole on checking behaviour.
We validated and evaluated the novel observing response task as a potential model of checking behaviour, by testing the hypothesis that chronic quinpirole treatment would selectively increase observing/checking behaviour, as it does in the open-field checking model.
In the observing response task, repeated quinpirole administration selectively increased checking behaviour in the form of observing lever responses.
In addition to checking behaviour, the observing response task measured how rats used the information available from checking.
The cognitive basis of components of checking behaviour can be addressed in rats using the observing response task.
Rats employed different strategies of observing behaviour, used information gained from checking to different extents and checking behaviour did not simply correlate with improved task success.
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During the sorting task time taken to complete the task, checking behaviours, hesitations, and anxiety were recorded.
The results offer preliminary support for the link between inflated responsibility and increased checking behaviours in children and add to the small but growing literature suggesting that cognitive models of OCD may apply to children.
It is unlikely that quinpirole induced a higher state of anxiety that could account for increased expression of checking behaviours.
We examined possible links between anxiety and checking behaviours by comparing observing responses with marble burying and elevated plus maze [33,34].
It may also be of value to assess other forms of neutralisation (e.g., crossing out or re-phrasing sentences) and to include checking behaviours (weight or mirror checking) to unpick this effect further.
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