The original motivation for permutation tests is to cross-check the p-values obtained by classical tests such as the Hypergeometric distribution to discover putative false positive pathways.
Users may identify most promising candidates by checking the p-value distribution and setting a customized p-value cutoff.
As PAK1 can be inhibited by autophosphorylation, we checked the p-PAK1 and found that SF condition could induce p-PAK1.
By checking the p-value histograms for RNA-seq dataset, we found that majority of p-values are very significant and its frequencies are very non-uniform for p >0.5.
Next, add the other 12 parameters one by one in order of the significance (Table 4) and then check the NRI and P value.
To further investigate the effect of ING4 on p-p65 and total p65, we performed immunofluorescence by confocal microscopy to check the change of p-p65 and the nucleus translocation of p65 in MMRU cells with ING4 overexpression or ING4 KD.
To further investigate the effect of JWA on ING4-regulated p-p65 and total p65, we performed immunofluorescence by confocal microscopy to check the change of p-p65 and the nucleus translocation of p65 in MMRU cells with ING4 overexpression, or JWA KD, or ING4 overexpression and JWA KD.
We did check that the P(S/PGL1) and P(S/PGL2) particles are very stable in a broad range of pH (from 2.5 to 10.0) and are resistant to spontaneous aggregation.
It is easy to check that p is the suffix of t', t' is the suffix of the substring s ′ [ 1, i - | q | ], and t ′ ∈ I x ′.
This data was confirmed analysing the allelic frequency, which includes the information corresponding to the DR3-homozygous individuals (p = 0.001; OR = 2.09) and by using the Arlequin software to check the DR3-positive haplotypes (p = 0.004 OR = 1.93).
