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CHASM score computation for these one million mutations took an additional 10 min and 33 s.
Applies the trained classifier to generate a CHASM score for each variant.
Genes with a CHASM score of at least 0.35 were considered significant for comparison with other functional analyses (Additional file 16).
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Outputs a list of the user-supplied mutations, with CHASM scores, P -values and Benjamini Hochberg estimated false discovery rate (FDR).
This null score distribution is used to compute a P -value for each variant supplied by the user (fraction of filtered passengers having CHASM scores less than or equal to the score of the variant).
Agüero was one of six City players inside the Barcelona area when his shot was blocked by Mascherano – a seventh, Pablo Zabaleta, had continued his run off the pitch – and Messi seized on the rebound and the chasm to score within seconds.
The racial achievement gap in passing rates has been cut in half on some tests, though the chasm in actual scores has not closed by as much.
But while it's easy for Knicks fans to contemplate conspiracy theories, a quick glance at the numbers (provided by NBA.com) reveals how the Heat's aggressiveness has helped contribute to the series' scoring chasm – at the free-throw line and beyond.
We shall provide additional tools to analyse other types of mutation and to rank genes based on somatic mutation frequencies, aggregated P-values of CHASM or VEST scores, ratios of truncating to non-truncating mutations and counts of recurrently mutated positions.
Test scores already show a growing chasm between rich and poor schools.
But in 2015, Democratic senators earned an average score of 92 while Republicans averaged just 5 — about as big a chasm between the two parties as possible.
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