Your English writing platform
Discover LudwigExact(4)
The charged nitrogen of HIS353 pointed towards the co-crystallized ligand.
Some key interactions are in common for -crebanine and ergotamine: A salt bridge is formed between the positively charged nitrogen of -crebanine (1) and the carboxylate of Asp1343.32 (Venkatakrishnan et al. 2013) (Fig. 4B), which is fully conserved in 5-HT and other monoamine receptors.
RH + NAD → NADH + H + R; From the hydride electron pair, one electron is transferred to the positively charged nitrogen of the nicotinamide ring of NAD, and the second hydrogen atom transferred to the C4 carbon atom opposite this nitrogen.
This binding is further increased by acid groups (COO–), which add an additional electrostatic bond interaction with the positively charged nitrogen of the muscle relaxant.
Similar(56)
Structures of the multidrug-binding repressor protein QacR with monovalent and bivalent cationic drugs revealed that the carboxylate side-chains of E90 and E120 were proximal to the positively charged nitrogens of the ligands ethidium, malachite green and rhodamine 6G, and therefore may contribute to drug neutralization and binding affinity.
This activity was demonstrated to be dependent on the length of the alkyl chain borne by the charged nitrogen atom of the quaternary ammonium moiety, and on the contact time.
These residues interact with one of the positively charged aminomethylquinolinium moieties of the bivalent drug Dq and with the positively charged nitrogen atom of Be (8).
The positively charged nitrogen atom of the ligand was expected to anchor to the highly conserved D3.32 of the aminergic receptors.
The design of the azo-ligand was inspired by a ferrocene derivative described by Liu et al. The positively charged nitrogen atoms of the azobenzene surfactant transfer water molecules and counterions to the vicinity of AuNPs, a process which assists in the formation of the interfacial azobenzene-CD inclusion complexes.
Here we examined the effect of substituting glutamate residues E57 and E58, which lie proximal to the positively charged nitrogen atoms of the bound drugs Be and Dq but are distal to the positive charge of MG (8), with the uncharged residues alanine and glutamine.
Atmospheric scientist Walter Lyons and his colleagues at FMA Research in Fort Collins, Colorado, noticed unusual behavior in storms over the plains: They triggered huge numbers of "sprites --ghostly red glowsprites --ghostlyogen moleculesprites --ghostly above violent stored.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com