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The effects of charge modification of PLGA micro-porous foams on DNA delivery and DNA transfection are investigated herein.
Tailor-designed l-lysine peptides (K4 and K20) were employed to modify the surface charge of PLGA foams using 1-ethyl-3- 3-dimethylaminopropyl carbodiimide and N-hydroxysuccinimide cross linkers and the effects of charge modification of PLGA were examined in three main aspects: DNA adsorption, DNA release properties and DNA transfection.
The enhanced photocatalytic activity may be due to the surface charge modification and surface electronic states passivation of CdS cores by the ZnS shells.
The effect of neither S13D nor Ser-13A was affected by 8-Br-cGMP, whereas the effect of wild type, S12A, and S12D was enhanced by 8-Br-cGMP, indicating the specificity of Ser-13 charge modification.
Particle size distribution, morphology, and surface charge modification play a vital role in determining the optical properties of nanoparticle and there is a growing interest in the controlled synthesis of silver nanoparticles among the all noble metals.
The effect of charge modification of photoimmunoconjugates (PICs) on their biodistribution in a xenograft model of ovarian cancer was investigated.
Similar(52)
The sensitivity of Hha to charge modifications had been previously observed and is consistent with its unusual high density of charged residues23,25.
To understand the possible mechanisms of how surface charge modifications on NPs affect mucin rheological properties, we examined the effect of different NP surface charges on mucin aggregation and gelation.
Due to low MS sensitivity for ions carrying more negative charges, it is still hard to detect negatively charged modification of proteins and enzymes in the HDL protein mixtures.
We further report several methods that were designed to overcome this problem: (1) use of a cathode material having a very negative potential of zero charge, (2) modification of the electrical double layer by using specifically adsorbing tetraalkylammonium hydroxides, (3) use of a rectangular wave pulse, and (4) use of chemically modified cathodes.
The targeting ability of nanoparticles depends on certain factors such as particle size, surface charge, surface modification and hydrophobicity.
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