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The present comparative evolutionary analysis implies that since the gene duplication event, the electric charges of the two PGI isoforms changed steadily through many charge-changing substitutions in both directions of charge change; only a few charged amino acid sites were specific to PGI-1 or PGI-2.
In a previous study, an analysis using the program HonNew [ 40] also failed to detect selection for charge-changing substitutions in teleost PGIs, leading to the conclusion that the charge change in the duplicate PGIs of teleosts may be selectively neutral [ 13].
Mr. Palazzo had been willing to let Annie continue running the front of the store, but when the Palombos came and Carmela was put in charge, change was inevitable.
The NHaseM (αS122A) and NHaseM (αS122D) mutants were entirely inactive due to the charge change of the side-chain group.
They suggested a combination of mechanisms including surface charge change and mineral dissolution, the former being the most effective and the latter having a positive but insignificant effect.
Any mutation that causes a charge change (e.g., D407N and D408N) results in loss of transport activity (Guan and Nakae 2001; Middlemiss and Poole 2004).
Similar(24)
Then the rape charge changes his mind.
Eventually, those in charge changed the rite of confession.
Who would imagine that a 5p charge changes human behaviour so decisively?
In particular, the new distribution of nuclear charge changes the way that the electron (or, more strictly, the atom as a whole) emits or absorbs light.
The width of the depletion region is expected to change as the surface charge changes [24 27].
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