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For drugs that are in the late stages of development, IVIVCs can play an important role in characterizing process-related changes and also simplify any scale-up or post-approval changes, or to obtain a bio-waiver.
Systematic identification of highly enriched functional themes and phenotypes revealed typical phenotype combinations characterizing process-defined groups of ID disorders, such as chromatin-related disorders and deficiencies in DNA repair.
Instead, we adopt another tool from statistical physics for characterizing processes by providing the joint distribution of the position and velocity at a given time, P x,v).
Characterizing processes as a function of signal level can usefully identify the performance expected for "typical" samples [ 14].
ER stores can be refilled by the well characterized process of store-operated Ca2+ entry (SOCE).
Biogenesis of β-barrel membrane proteins is a complex, multistep, and as yet incompletely characterized process.
Groundwater nitrification is a poorly characterized process affecting the speciation and transport of nitrogen.
Hep phosphorylates and activates the Drosophila JNK, Basket (Bsk) [7] and null mutations in hep lead to a defect in dorsal closure, a well characterized process in the Drosophila embryo that entirely depends on JNK signaling [4], [7].
Increase in ethylene production by pathogen infection is a well characterized process.
Because noise factors are not considered, these algorithms cannot be used to characterize processes.
Since the parameters of codon frequencies characterize processes that are independent of the selection on overlapping regions, we estimate these frequencies using the non-overlapping regions of each gene.
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