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Instead of characterizing function in model systems, exome sequencing potentially allows for evaluating the functional consequence of pathogenic mutations directly in humans.
There is considerable scattered literature about characterizing function spaces that depends only on wavelet coefficients: how the wavelet coefficients actually function, how they process information or are affected by individual's aspects.
In centralized DCA schemes, a channel is selected for a new call from a central pool of free channels, and a particular characterizing function is utilized to select one of the available free channels.
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Tm1631 is a member of the domain of unknown function 72 (DUF) family in the Protein family (Pfam) database, a protein domain that has no characterized function [1].
αSNAP has a well characterized function in SNARE complex disassembly.
The provision of metabolic energy by oxidative phosphorylation (OXPHOS) is the best characterized function of mitochondria.
The neuropeptide S receptor gene (NPSR1), codes for a 7-transmembrane G protein-coupled receptor (GPCR) of poorly characterized function.
For example, AFM has not been reported to be related to cancer, and C6orf155 does not have a characterized function.
Both genes code for RNA binding proteins of poorly characterized function, hence they were not identified by data mining of protein-protein interaction databases.
Estimates vary, but there is a general consensus that 50 70% of ORFs in newly sequenced genomes are described as having unknown or poorly characterized function [1], [6], [7].
Their best characterized function is catalysis of maturation of spliceosomal and ribosomal RNA by guiding methylation and pseudouridylation of target RNAs in sequence-specific manner [39].
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