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Using a transcriptome-powered targeted proteomics screen, we discovered a gene regulatory circuit involving the nuclear factor CYCLON which characterizes aggressive disease and resistance to the anti-CD20 monoclonal antibody, Rituximab, in high-risk B-cell lymphoma.
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Importantly, the molecular resemblance of basal cells to anaplastic PCa and CRPC provides a common molecular understanding of these diverse and poorly characterized aggressive PCa subtypes and implicates basal cells as the cell-of-origin for these variant PCa (Fig. 7d).
(59– 61) Functional and morphological heterogeneity characterize aggressive glioblastoma and contribute to invasion, metastasis and drug resistance.
Here, we have identified a PR-dependent gene signature more likely to characterize aggressive tumors.
A further explanation might be linked to the initial amplified resistance and ability to develop drug independent growth potential that characterizes more aggressive BCCs.
This is the first report documenting that MGB-2 expression characterizes less aggressive forms of EOC and is correlated with a favorable outcome.
The crowds and what Mr. Emery characterized as aggressive overbuilding have become too obnoxious.
Kalanick, whose public persona has been variously characterized as aggressive, juvenile, and brash, is both reviled and beloved in Silicon Valley.
Triple-negative breast cancer is characterized by aggressive tumours whose cells lack oestrogen and progesterone receptors and do not over-express HER2.
America is in the midst of an opioid epidemic characterized by aggressive prescribing practices, highly prevalent opioid misuse, and rising rates of prescription and illicit opioid overdose-related deaths.
The professional women of color I spoke with told me they've been characterized as aggressive, out-of-character, or too emotional when they advocate for themselves in the workplace.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com