The major adverse side effect is hypoglycemia, which can be prolonged and life threatening, but such episodes, characterized by a need for assistance, coma, or seizure, are infrequent.
Like many of his colleagues, Dodes speculates that Trump fits the description of someone with malignant narcissism, which is characterized by grandiosity, a need for admiration, sadism, and a tendency toward unrealistic fantasies.
This condition is referred to as 'EPO resistance', which is characterized by either a need for higher doses of EPO to maintain the recommended hemoglobin (Hb) or even a lack of response to EPO at all [ 6].
Recent commentaries have stressed a need for characterizing sub-visible particle populations in protein drug formulations (1).
It was known to be an oligosymptomatic chronic nephropathy characterized by prominent tubulointerstitial damage, a need for RRT at around the sixth decade of life and a high incidence of upper urinary tract urothelial carcinoma [ 10].
11 Although there is a need for characterizing and quantifying NeP concurrently with its identification in patients with various NeP conditions, to our knowledge, no other NeP instrument has yet been specifically validated for distinguishing between levels of average pain severity.
Thus, there is a need for well characterized animal models for further investigations that allow translation to the human situation.
The rapidly increasing array of disease-specific treatments creates a need for methods to characterize disease severity (prognosis), predict response to specific therapies (prediction), and to measure the efficacy of treatment (response).
Given existing knowledge gaps, there is a need for research that quantitatively characterizes spatiotemporal variation of suspended sediment particle size distribution (PSD) in contemporary watersheds.
Genomics-driven growth in the number of enzymes of unknown function has created a need for better strategies to characterize them.
