All class I transporters characterized to date are targeted to the tonoplast (Pardo et al. [2006]).
This might be due to the relatively small number of androgen and/or estrogen-related targets characterized to date.
A number of genes participated in HM uptake, transport, sequestration and detoxification have been functionally characterized and transformed to target plants for enhancing phytoremediation efficiency.
Interestingly, similar system based on isolated mitochondria was also used to characterize compounds designed to target Bid to treat disorders associated with the activation of such pro-apoptotic protein [ 18].
With increasingly sensitive and precise technologies for the detection and molecular profiling of rare cells, the genomic interrogation of CTCs may offer a powerful new tool to characterize, and someday to target, the dominant tumor subclones responsible for treatment resistance or metastatic progression.
This antibody library is designed to target marginally characterized membrane-associated and secreted proteins.
Yet, immunomodulatory properties of lymphoid tissue stroma, particularly toward CD4+ T cells, remain insufficiently characterized by lack of tools to target antigens for presentation by stromal cells.
We used well characterized trafficking signals to try to target PAM to different subcellular locations in CHO cells producing an engineered PAM substrate, Fc-AP-GLP1-Gly [ 19].
Identifying and characterizing potential new therapeutic agents to target cell proliferation may provide improved treatments for neoplastic disorders such as cancer and polycystic diseases.
These interactions between cancer cells and their environment have been more difficult to characterize and target for therapeutic intervention than intrinsic changes to cancer cells, since in vitro models of cell-cell interactions are difficult to establish and standardize, especially at the scale necessary for drug screening.
