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In this study we characterized targeting efficiency and physiology of penicillinG producing Penicillium chrysogenum strains, in which the KU70 or KU80 homologues hdfA and hdfB had been deleted.
Its mechanism of action (MOA) is well characterized, targeting viral entry by binding to high-mannose oligosaccharides on gp120.
Well characterized targeting signals known to direct proteins to the endoplasmic reticulum (ER), TGN, endosomes (Endo) and lysosomes (Lyso) were used (Fig. 1a).
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The proportion of observed agreement (by different vaccines or between countries) was investigated to characterize targeting patterns of prioritization and subsidy.
This paper describes a study conducted to characterize targeted aldehydes in microenvironments in Sacramento, CA, and Milwaukee, WI, and to improve our understanding of the impact of the urban environment on human exposure to air toxics.
Before then, its use was limited to a focused approach for characterizing targeted proteins within samples.
These assays have the potential to characterize targeted drugs in pre-clinical studies and identify predictive biomarkers that could guide personalized treatment decisions.
The hypothalamic-pituitary-adrenal axis is probably the best characterized target.
At present, the prostate-specific membrane antigen (PSMA) is the most widely characterized target antigen in PCa.
This genome-wide screen validated previously characterized targets or helped identify potentially new modes of action for over half of the compounds tested, providing proof of this principle for analyzing the modes of action of clinically relevant compounds.
A significant challenge in the post-genomic era is determining how to prioritize differentially expressed and poorly characterized targets in cancer-related microarray profiling studies.
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