Sentence examples for characterized roles from inspiring English sources

The Syk protein-tyrosine kinase, a well-characterized modulator of immune recognition receptor signaling, also plays important, but poorly characterized, roles in tumor progression, acting as an inhibitor of cellular motility and metastasis in highly invasive cancer cells.

They identified 16 significantly mutated subnetworks that comprise well-known cancer signaling pathways as well as subnetworks with less characterized roles in cancer, including cohesin, condensin, and others.

SR proteins have well characterized roles in both constitutive and alternative pre-mRNA splicing.

The cytoskeletal protein actin has well characterized roles in many aspects of neuronal development and function from growth cone dynamics to the remodeling of dendritic spines [1], [2].

However, if such a role exists, it does not appear to generally involve interactions with the Bur or Ctk complexes or their characterized roles in transcription.

There are other examples of genes conserved between flies and vertebrates, that despite having well characterized roles in vertebrates, appear to have elusive functions in flies.

The best characterized role for ubiquitination of membrane receptors is to negatively regulate signaling by targeting receptors for lysosomal degradation.

These data extend the proposed functions of the tegument from that of its well characterized role in nutrient uptake to that of waste metabolite excretion.

The data reported here provide evidence that the function of the tegument extends from its well characterized role in nutrient uptake to include waste metabolite excretion.

IL-6 was chosen for further investigation to determine the signaling pathway that may underlie altered expression based on its well characterized role in hematopoiesis.

Another well characterized role of PRMTs is the regulation of RNA processing.