The other two MutS homologs belong to the poorly-characterized MutS2 supergroup of which most of the characterized members do not function in DNA repair [108], [110], [112].
Notably, supergroup H is one of the largest supergroups within the NRT1/PTR family but lacks any characterized members, highlighting the need for further functional characterizations.
The integrins are one of the best characterized members of the adhesion molecule family that is upregulated in angiogenic endothelial cells found in tumors and certain inflammatory injuries.
Although all characterized members of the family catalyze the OSBS reaction, this family is extraordinarily divergent, with some members sharing <15% identity.
Structurally characterized members of this family include enzymes with β-galactosidase activity (Escherichia coli LacZ), β-glucuronidase activity (Homo sapiens GusB), and β-mannosidase activity (Bacteroides thetaiotaomicron BtMan2A).
All characterized members of the Microviridae are strictly lytic, unable to lysogenize their hosts [10].
Previous studies have characterized members of the Hipk protein family as transcriptional co-repressors [60], [63].
The best characterized members of the Rho family of GTPases are RhoA, Rac1, and Cdc42; each of which is associated with unique phenotypes and functions [1], [2], [3].
Another recent paper reports the same compound as a water solvate and argues that it must be trinuclear, like other characterized members having the same stoichiometry [20] [24].
This family of cytokines comprises a single IFN-β, more than 13 IFN-α, and several other less well characterized members [2], [3].
The characterized members of this IS family contain two ORFs.
