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Exact(49)
Tm1631 is a member of the domain of unknown function 72 (DUF) family in the Protein family (Pfam) database, a protein domain that has no characterized function [1].
αSNAP has a well characterized function in SNARE complex disassembly.
The provision of metabolic energy by oxidative phosphorylation (OXPHOS) is the best characterized function of mitochondria.
The neuropeptide S receptor gene (NPSR1), codes for a 7-transmembrane G protein-coupled receptor (GPCR) of poorly characterized function.
For example, AFM has not been reported to be related to cancer, and C6orf155 does not have a characterized function.
Both genes code for RNA binding proteins of poorly characterized function, hence they were not identified by data mining of protein-protein interaction databases.
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The most well-characterized function of SMN is its role in snRNP biogenesis [30], [31].
The best-characterized function of the SMN complex is in the assembly of the Sm core on spliceosomal snRNAs [22], [23].
The best-characterized function of VHL is as an adaptor for targeting HIFα for proteolytic degradation [5], [6], and has been considered to be the major tumor suppressor activity associated with VHL.
SNPs with well-characterized function do not generally have the same requirement for adjustments for multiple comparisons due to a well-founded a priori hypothesis of their potential association with a cellular function.
In addition to its well-characterized function as a carbohydrate and non-native-peptide-recognizing chaperone and Ca2+-signaling molecule in the endoplasmic reticulum [3], CRT was shown to play a key role in the MHC class I assembly pathway [4], [5].
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