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If the enzymes responsible for formation of M2 are different from the well characterized conversion pathway of leflunomide to teriflunomide, reduced activity of CYP2C19 is likely to result in increased formation of M2, which may be the toxic metabolite contributing to the side effects associated with leflunomide.
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These studies reveal the value of characterizing conversion events in the context of studying gene clusters in complex genomes.
We developed an easy tool to profile individual intraprostatic enzymatic activity by characterizing conversion pathways in an intact tissue environment.
In summary, we developed an easy tool to profile individual intraprostatic enzymatic activity (steroid map or fingerprint) by characterizing conversion pathways in an intact tissue environment from fresh biopsies.
Some gene conversion hotspots were characterized by conversion tracts initiating near nucleotide repeats within coding regions, and similar repeats were found within concertedly evolving cuticular protein genes in Anopheles gambiae.
The polymers produced were characterized for conversion, composition and molecular weight.
Magnetic structure of iron oxides and sulphides was characterized by Conversion Electron Mössbauer Spectroscopy (CEMS).
Within 1 to 4 weeks after exposure to asbestos, differentiated rodent and human tracheobronchial epithelial cells in organ culture undergo squamous metaplasia, a putative preneoplastic lesion characterized by conversion of mucociliary cell types to keratinizing cells.
To characterize gene conversion in rice, we have defined 626 multigene families in which 377 gene conversions were detected using the GENECONV program.
When Toklas became a Catholic, in 1957, she went so far as to characterize the conversion not as a repudiation of Judaism but as a return to the Church.
Spectroscopic ellipsometry has allowed to characterize the conversion layer for the electrophoresis treatment.
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