This field of research is particularly relevant to the understanding of rheumatic diseases, which are characterized by profound alterations of bone architecture aside from immune activation.
End-stage renal disease (ESRD) is characterized by profound dyslipidemia and enhanced oxidative stress.
It is characterized by profound emotion and deals with themes of death, anguish, despair, or religious doubt.
Chronic fatigue syndrome (CFS) is characterized by profound fatigue accompanied by disturbances of sleep, cognition, mood, and other symptoms.
Usually diagnosed in early childhood and characterized by profound impairments in social interaction, communication, activities and interests, this neurological disorder encompasses a wide spectrum of abilities.
Mutations in the MYO7A gene are the most common cause of Usher syndrome type 1, characterized by profound congenital deafness, vestibular arreflexia, and progressive retinal degeneration.
The clinical picture is characterized by profound hypoxemia, ventilation perfusion mismatch, and restrictive lung disease [11].
Its most severe form, septic shock, is characterized by profound circulatory, cellular, and metabolic abnormalities [1].
Severe combined immunodeficiency (SCID) is a syndrome of diverse genetic cause characterized by profound deficiencies of T, B and sometimes NK cell function.
More modestly, it would show only that wealthy welfare states may do so as long as the world is characterized by profound international inequality.
However, a reeler-like phenotype characterized by profound dyslamination of all cellular layers was observed in double Pafah1b1+/− Apoer2−/− mice (Fig. 6).
