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Following removal of known anti-inflammatory drugs, we identified ten potent inhibitors of wound-induced neutrophil recruitment that had not previously been characterized as general anti-inflammatories.
Employing a simple tail fin wounding assay, we identified a number of drugs with anti-inflammatory activity that had not previously been characterized as general anti-inflammatory agents.
For subsequent validation and translation experiments, we decided to focus on the ten most significant hits that had not previously been characterized as general anti-inflammatory agents.
Via a drug screening protocol, the authors identified a number of drugs (repositioned drugs) with the ability to suppress neutrophil recruitment that had not previously been characterized as general anti-inflammatory agents.
The second factor was best characterized as general negative affect; it was dominated by "cry more than usual" and notably included "thoughts of ending your life" and four items that also loaded on the first factor.
By interrogating a library of 1280 approved drugs for their ability to suppress the recruitment of neutrophils to tail fin injury, we identified a number of drugs with significant anti-inflammatory activity that have not previously been characterized as general anti-inflammatories.
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Brady has been characterized as a General Patton-type leader, an unflappable practitioner of pocket footwork and the possessor of Yoda-like wisdom beyond his 24 years.
Resistance groups consisted of seven factions characterized as two general groups: fundamentalists and moderates.
Although previously characterized as a general chaperone, it has now been shown that SctO/FliJ has a coiled-coil structure that inserts into the central cavity of the ATPase hexamer, in a manner directly analogous to the ATP synthase, and that it is capable of rotation within a chimeric V1V0 assemblysembly [ 25].
Germanium compounds in which germanium is in the +2 oxidation state are well characterized as solids, and in general they are readily oxidized.
Together, the data indicated that genes in all classes are required for essential functions characterized as cell development under general stress.
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CEO of Professional Science Editing for Scientists @ prosciediting.com