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Beclin-1 is a protein characterized as essential for the initiation of autophagy.
While the role of cell wall plasticity in bacterial fitness is well documented, none of the S. aureus cell wall hydrolases have been characterized as essential for bacterial growth, presumably due to the high level of genomic redundancy in this pathogen, which produces several autolytic enzymes with similar activities (see MiST Database: http://genomics.ornl.gov/mist) [15], [16].
However, this gene is characterized as essential by genetic footprinting but nonessential by the Keio collection and PEC database.
And the 2 genes are both characterized as essential by studies of both the Keio collection and genetic footprinting [ 14, 19].
Moreover, the gene fbaA, which encodes ALDO, is characterized as essential by all the Keio collection, genetic footprinting and the PEC database [ 14, 19, 20].
Furthermore, glutamine residues have been characterized as essential for entry of enveloped viruses into their host cells; without which the viral capsid is unable to fully fuse with the bacterial cell membrane [ 28].
Similar(51)
This combined analysis demonstrated that the parameters were, in most cases, characterized as either essential or modulatory using this set of perturbations, where essential parameters were only identified using wide perturbations.
Moreover, PTHLH has been characterized as the essential growth factor exhibiting pleiotropic effects, including tumor cell growth, differentiation, invasion, and death 15, 16.
Among the downregulated genes in the cspC strain at stationary phase, the sciP gene was also characterized as an essential gene [ 28].
A parameter was characterized as modulatory if (or ) and as essential if (or ), and the parameter characterizations of the original and hybrid models were compared.
Together, the data indicated that genes in all classes are required for essential functions characterized as cell development under general stress.
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