However, compared to the well characterized and documented lung toxicities of the conventional chemotherapeutic agents, these newer agents continue to exhibit a reduced but significant incidence of potentially toxic effects impacting normal lung tissues.
To simplify the further bioinformatics analysis, we only focused on the 52 genes whose function had been well characterized and documented in GO.
Wild type controls were not included in this study because deficits in huAPP/PS1 mice compared to wild type controls have already been extensively characterized and documented in the literature [ 7, 10, 11, 31].
The antibody used in our studies has been well characterized and documented by peptide antigen and recombinant Wnt5a blocking experiments and IHC and Western blot of PCa cells after silencing Wnt5a expression [ 10, 18].
Thus, characterizing and documenting the relationships (i.e., the direction and magnitude of associations) among potential confounders, exposures, and outcomes of interest is critical.
ADEs that are reported to the FDA tend to be severe, and potentially common, but less serious side effects are more difficult to characterize and document.
The Cancer Genome Atlas (TCGA), a project initiated by the National Cancer Institute (NCI) and the National Human Genome Research Institute NHGRII) of the United States in 2006, continues to characterize and document a number of tumor or cancer samples.
Pivotal influences and key events in the history of the development of the DNT guideline (Table 2) include both research on test methods development and efforts to characterize and document the sensitivity, reliability, and performance of the test methods, including a number of intralaboratory collaborative efforts.
Although not reported in the literature, the paroxetine mesylate case is an outstanding example that underpins the necessity to thoroughly investigate, characterize, and document APIs and speciality chemicals.
However, well-characterized and documented preparations of synthetic soluble Aβ oligomers have been reported by numerous researchers [ 19, 40, 43, 95, 100, 107, 108, 111, 168- 170] that generate soluble Aβ oligomers with little or no detectable fibrillar Aβ species.
Based on the results of geological and geophysical investigations, we reconstructed the palaeoform parameters, characterized its infilling, and documented spatial lithological variability of the deposits and the cultural layer.
