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Behaviorally characterized aging rat models provide direct insight into the neurobiological underpinnings of discrete forms of cognitive change with age that can direct the design of new therapies to protect or rescue cognition in later life.
Additionally we characterized aging CD8+ T cells for other senescent markers.
This study also observed a stochastic element to aging; various cells and tissues deteriorated at different rates between individuals, and no single pathology or series of pathogenic changes characterized aging in all individuals.
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All three genes were identified in a microarray analysis of the hippocampal subfields in cognitively characterized aged and young Long Evans rats.
Behaviorally characterized aged and young rats were anesthetized with isoflurane and transcardially perfused with 0.1 M phosphate buffer saline at room temperature followed by ice-cold 4% paraformaldehyde in 0.1 M phosphate buffer (PB).
Means to characterize aging effects are presented.
Part of the hormonal and metabolic changes observed in older adults could be secondary to the decreases in sleep duration and quality that characterize aging.
characterize "aging" as a spiritual journey.
We plan to further characterize aging phenotypes and survival in more wild-derived N. furzeri isolates and in the two sympatric species N. orthonotus and N. sp. aff.
These analyses confirmed known changes that characterize aging yeast: increased cell size and bud scars, and decreased population viability.
This loss of DNA methylation during aging may contribute to the signature genomic instability and shortened telomeres that characterize aging cells [ 57, 58].
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