While it was not within the scope of this study to identify these proteins and characterize affected signaling pathways and downstream events, we have identified an aberrant expression and localization of two important signaling molecules, PKCβII and APC.
80 Thus, different strategies can be developed taking into consideration the special conditions which characterize affected skin and exploiting them to achieve a more selective delivery of the drug.
We characterized mutants affected in genes encoding proteins involved in HG biosynthesis (quasimodo2-1; qua2-1) and methylesterification (pectin methylesterase 3; pme3).
To characterize patients affected by a uniquely severe, rapid-onset chorioretinopathy (ROC) phenotype of ABCA4 disease.
Groundwater nitrification is a poorly characterized process affecting the speciation and transport of nitrogen.
There are currently more than 600 diseases characterized as affecting the central nervous system (CNS) which inflict neural damage.
The paper proposes an imprecise Fault Tree Analysis in order to characterize systems affected by the lack of reliability data.
This study is the first to implement SDI and PDI to characterize concrete affected by delayed ettringite formation (DEF).
The 5-HTTLPR polymorphism has been well characterized to affect 5-HTT expression: The S and L alleles in the 5-HTTLPR result in lower and higher levels of 5-HTT expression, respectively [25].
The functional role of a number of downstream effectors of c-di-GMP has been characterized as affecting exopolysaccharide (EPS) production, transcription, motility, and surface attachment (Caly et al., 2015; Camilli and Bassler, 2006; Ha and O'Toole, 2015; Pesavento and Hengge, 2009).
As all the characterized mutations affect differently the enzymatic activity of GNE, but result in similar phenotypes, it is questionable that an altered enzymatic function of GNE triggers the disease mechanism.
