Our analysis of COSMIC mutations and other cancer mutations did not find an enrichment for high B-SIFT scores in COSMIC (Fig. 4A), implying that the majority of characterized "activating" cancer mutations fall into this category of deleterious mutations that result in functional activation and are thus indistinguishable from other deleterious mutations by B-SIFT.
The most extensively characterized activating methylation is H3K4[ 8- 10], while the H3K9 [ 11- 13] and H3K27 [ 14- 16] methylations are thought to lead to repression and inactivation.
This study characterizes activated carbon fiber cloth's (ACFC's) electrical resistivity and the change in resistivity from isobutane adsorption.
Iodine number is a fundamental parameter used to characterize activated carbon performance.
To address these two questions, we have decided to investigate stem cell mediated functional improvement by use of a non-invasive imaging technique, in particular functional Magnetic Resonance Imaging (fMRI), which allows to detect, localize and characterize activated cortical representation fields to a specific sensorimotor stimulus.
Smooth muscle actin (α-SMA) and PDGFβ-R expression characterize activated cancer-associated fibroblasts [ 14].
In this study, a time-course experiment was conducted to characterize activated and repressed genes in the inflorescence meristems of Jatropha following cytokinin treatment using transcriptome sequencing by a 454 GS FLX Titanium instrument.
JB6 cells, a promotion sensitive (P +) mouse epidermal cell line, has enabled the study of genetic susceptibility to promotion of cell transformation, and thus provides a unique cell model to characterize activated COX-2 in pre-neoplastic cells (Dong et al., 1994).
There is still significant improvement that is possible in the field of detecting and characterizing activating mutations, but B-SIFT provides a valuable starting point for such analyses.
Xenopus laevis oocytes have well characterized Ca2+ activated Cl- currents (CaCC) [23], [24] and both voltage activated Ca2+ channels and store operated Ca2+ currents [24], [25].
Various leukemia antigens have been characterized and activated leukemia-specific CD4+ and CD8+ T cells have been documented.
