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However, the methods developed in this study should also be readily adaptable for testing compounds that have been less well characterized, accompanied by an appropriate analysis of their solubility, stability and metabolic turnover.
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Because of the relevance of mtDNA for energy production and oxidative stress generation, mtDNA haplogroups and clusters have been intensively investigated in relation to aging and neurodegerative diseases characterized or accompanied by cognitive impairment, including Alzheimer's disease [ 10], and frontal lobe disease [ 11].
While morphological changes during single cell adhesion and spreading are well characterized, the accompanying alterations in cellular mechanics are scarcely addressed.
Preeclampsia is characterized by hypertension accompanied by proteinuria.
Sighing speech was often characterized by breathiness accompanied by a low decreasing pitch intonation (80% of the "sighing speech" tokens).
We biochemically characterized the PTMs accompanying in vitro NETosis and broadly profiled the in vivo humoral immune responses of patients with SLE and mice immunized with NETS by applying multiple proteomic approaches, including autoantigen microarrays [ 35], PTM-modified histone peptide arrays [ 36] and a high-throughput immunoblotting assay (modified Multiple Antigen Blot Assay, MABA) [ 37].
Rat anti-Thy1.1 nephritis models are characterized by MC proliferation accompanied with ECM deposition.
Chronic fatigue syndrome (CFS) is characterized by profound fatigue accompanied by disturbances of sleep, cognition, mood, and other symptoms.
Radiocarbon ages indicate that most large streams were characterized by slow aggradation accompanied by cumulic soil development from ca. 11,500 to 10,000 14C yr B.P. In the valleys of some large streams, such as the Ninnescah and Saline rivers, these processes continued into the early Holocene.
Subacute disease is characterized by fluctuating fever, accompanied by depression and loss of appetite.
Epilepsy is a major neurological disorder characterized by spontaneous seizures accompanied by neurophysiological changes.
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