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Since PDGF has been consistently implicated in cell proliferation and extracellular matrix accumulation, which characterize progressive glomerular disease [29], and since c-Src is an important component of the PDGF signaling pathway [30], we first investigated whether c-Src is induced in glomeruli of proliferative glomerulonephritis.
The recent introduction of oligonucleotide microarrays designed for the genome-wide typing of SNPs, with a resolution of 100 200 kb, has been used by Hall's group to characterize progressive LOH in samples from children with ALL who relapse after chemotherapy (Irving et al, 2005).
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It however abandoned the complex song structures and interplay between music and vocals that had characterized progressive rock.
PDGF has been consistently implicated in the cell proliferation and extracellular matrix (ECM) accumulation that characterizes progressive glomerular diseases [ 30, 31].
Based on our experience, these symptoms characterize a progressive phase of disseminated tumors, causing death within approximately 24 48 hours.
Spinocerebellar ataxias are progressive neurodegenerative disorders characterized by progressive cerebellar features with additional neuro-axis involvement.
Progressive vaccinia (vaccinia necrosum)- Progressive vaccinia is a severe, potentially fatal illness characterized by progressive necrosis at the site of vaccination.
Diastrophic dwarfism is characterized by progressive, crippling skeletal deformities.
Systemic sclerosis is characterized by progressive, microvascular injury and fibrosis in multiple, affected organs.
The muscular dystrophies are a group of hereditary disorders characterized by progressive muscular atrophy and weakness.
This disorder is characterized by progressive trismus and the need for repeated surgeries.
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