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However, relatively little is known about CI composition in the unicellular protists, the characterizations of which are essential to our understanding of CI evolution.
In the 1990s, large-scale mutagenesis screens (Driever et al., 1994; Mullins et al., 1994; Haffter et al., 1996) provided researchers with thousands of mutants, the phenotypic characterizations of which illuminated numerous cellular events in vertebrate development and foreshadowed the power of zebrafish as a human disease model.
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There are many points in the debates in which misunderstandings may be avoided by a precise characterization of which of the units of selection questions is being addressed.
But Priest's proposal has difficulties of its own.[21] To mention some of them, Priest does not give a principled characterization of which properties are existence-entailing and which are not (which looks quite similar to the problem with the nuclear-extranuclear distinction which Priest points out in the above quotation).
Together, our study describes the discovery of the first drug-like activators of IDE, the characterization of which provides several new insights into the mechanistic basis for pharmacological activation of IDE.
In addition, we used SSc skin-derived polarized T cell clones (generation and characterization of which are described elsewhere [ 36]).
The six CerS have distinct but overlapping acyl-chain preference, characterization of which has advanced understanding of the regulation of ceramide synthesis [ 32– 32].
Another aspect of mutagenic drug treatment that can be readily demonstrated by ViVan is dosage-dependence, characterization of which would normally require classic sequencing of hundreds of molecular clones (Levi et al., 2010).
This does not imply that these methodologies cannot learn from one and other as there are functional and/or biomolecular relationships between many of these elements, the characterization of which might benefit from more comprehensive approaches.
This last point introduces the idea that the Dnmts, despite their central role in the DNA methylation machinery, work in a network of proteins working in concert, the characterization of which will be a new step in the understanding of molecular mechanisms promoting the resistance of apoptosis in glioma.
ABC and similar coalescent approaches have opened up a variety of options to study the population dynamics of medically important vectors and pathogens, whose demographic and evolutionary histories are poorly understood, and a better characterization of which will greatly enhance our ability to fight infectious diseases around the world.
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CEO of Professional Science Editing for Scientists @ prosciediting.com