Sentence examples for characterization of pathways from inspiring English sources

Remarkable findings included the discovery of germline and somatic mutations of BRCA1-associated protein 1 (BAP1) in patients, and the genome-wide characterization of pathways altered in MM that could be exploited to design novel therapeutic approaches.

Hence, the molecular characterization of pathways regulating chemosensitivity is a central prerequisite to improve cancer therapy.

Crucial tasks for the near future are the firm identification and characterization of pathways involved in melanoma suppression.

Characterization of pathways that drive metastasis may yield important new insights for better application of targeted therapies.

Using this novel comparison system, our comprehensive survey of endosperm proteomics in the notched-belly mutant provides a valuable proteomic resource for the characterization of pathways contributing to chalkiness formation at molecular and biochemical levels.

We have characterized changes in DNA methylation in the superior temporal gyrus of patients with Alzheimer's disease, highlighting novel loci that facilitate better characterization of pathways and mechanisms underlying Alzheimer's disease pathogenesis, and improve our understanding of epigenetic signatures that may contribute to the development of disease.

For enzymes that function in metabolic pathways, characterization of the pathway in which the enzyme participates facilitates the assignment of both the correct in vitro activity as well as the physiological role of the enzyme.

The characterization of signaling pathways induced by TCR and/or costimulatory receptor activation is critical, since these pathways are excellent targets for novel therapies for human disease.

This first report, if followed by other similar reports, will eventually allow full characterization of signaling pathways in all peripheral tissues in humans as well as the comparative evaluation of human versus animal signaling pathways.

As such, detection and characterization of leakage pathways from storage formations into overlying formations are required.

Inhibitors of the protein kinase family not only hold great promise as therapeutic agents, but are also of profound utility in the characterization of signaling pathways.