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Since CRC and its prognosis are influenced by a range of tumor characteristics, we next explored which other clinically relevant endpoints, in addition to outcome, could be predicted from our in-depth molecular data and assessed non-invasively.
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Since our data indicated that KDM1A is highly relevant for critical biological characteristics of medulloblastoma, we next aimed to identify important target genes of KDM1A.
Since there is emerging evidence on the importance of the location of CpG dinucleotide hypermethylation in relation to gene expression but also clinicopathologic characteristics of tumors, we next performed a systematic correlation analysis between SLC22A1 mRNA expression and quantitative DNA methylation of individual CpG sites within the SLC22A1 promoter region.
Because the PCA indicated that the different image categories each have characteristic power spectra, we next asked what these differences might be.
Using the area under the receiver operating characteristic (ROC) curve approach, we next calculated potential cut-off values to separate patients with AH from those without AH based on White Cell Count and Platelet Count.
Because N5 appears to retain some of the folded characteristics of the parent pZ, we next tested whether changes that would disrupt tertiary structure integrity would affect the ability of N5 to stimulate channel function.
Since our results demonstrated a correlation between predicted hypoxia response and HIF-1α mRNA expression in both basal breast tumors and HER2 related tumors with basal-like characteristics, including subgroup 7 tumors, we next investigated whether HIF-1α mRNA expression directly regulated the exaggerated hypoxia-induced gene expression in these cells.
Since the morphological growth, adhesion and migration alterations produced by chronic exposure to CSE were reminiscent of phenotypes characteristic of oncogenically transformed cells, we next asked whether CSE-treated cells were capable of anchorage-independent growth by culturing them in soft agar.
We next compare key characteristics of our good signatures to the average of the signatures that are triggered in our infrastructure, which uses the default VRT and ET rulesets.
We next investigated the characteristics of chemical-induced LD fusion in 3T3-L1 adipocytes.
We next compared clinical characteristics of RCC patients with and without a skewed TCRVβ repertoire.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com