In this review, we enumerate the published specific inhibitors of PTP1B, discuss the structure activity relationships by analysis of their X-ray structures or docking results, and summarize the characteristic of selectivity related residues and groups.
The validation characteristics consisted of selectivity, linearity range, precision (repeatability and time-different intermediate precision), bias and robustness.
The ATPS shows characteristics of high selectivity and is easily to scale up.
The binding of the receptors and their ligands has the characteristics of specificity, selectivity, strong affinity, and obvious biological effect.
Considering the characteristics of specific selectivity, chemical stability, and easy preparation, molecularly imprinted polymers (MIPs) were proven to be a suitable alternative for selective SPME coating.
This suspension has the unique characteristics of tumour selectivity and continuous release of active molecules, and it is expected to demonstrate better antitumour effects and improved safety, compared to formulations that are currently used.
Unfortunately, they rarely display the required characteristics in terms of selectivity, affinity, stability, and targeting with regard to the desired application.
During photo-diode array/fluorescence detector method validation, satisfactory analytical characteristics, in terms of selectivity, recovery (72.7% 109.1%), precision (inter-day RSDs <9.6%), sensitivity (limits of quantification ranged from 2.1 μg kg−1 to 120.0 μg kg−1) and linearity (R2 all higher than 0.9984), were achieved.
Moreover, the electrophysiological studies over the past half of century indicate two key characteristics of VGCCs: ion selectivity and voltage gating (Favre et al., 1996; Sontheimer et al., 1996; Sun et al., 1997; Catterall, 2000), both of which are essential for the normal electrical signaling.
