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Thus, genes that were highly represented in the IMCNs were identified and then inspected to see their frequency characteristics of mutation and methylation events.
To clarify the beneficial characteristics of mutation induction by C-ion irradiation, whole-genome investigation of mutations such as missense and silent mutations is needed.
However, other characteristics of mutation catalogs can also be included as features of mutation signatures and analyzed by NMF [ 8, 76].
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More recent methods exploit genomic characteristics of mutations, such as mutual exclusivity, to identify oncogenic modules [ 8– 10].
42 A major benefit of this method is that the characteristics of mutations affecting fitness can be estimated without having to directly identify the mutations involved.
Our next work is to evaluate the characteristics of mutations in the S gene using a reverse genetic approach in animal experiments.
In this study none of the 171 E. dispar isolates showed characteristics suggestive of mutation by SSCP analysis, perhaps due to the screening of only a 174 bp region of the gene.
Dorsal closure phenotypes are characteristic of mutations in components of the JNK signalling pathway (37– 37).
Significantly, wavy coat phenotypes are characteristic of mutations in the EGFR pathway (Schneider et al., 2008).
Both these properties are characteristic of mutations that cause hypertrophic cardiomyopathy in a variety of contractile proteins that have been studied at the single filament level.
This phenotype is characteristic of mutations in Notch pathway genes and can be visualized by staining with antibodies against a marker for neuronal cells, ELAV.
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