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To examine prevalence, characteristics, interventions, and mortality of very low birth weight (VLBW) infants with trisomy 21 (trisomyrisomy 18 (trisomyrisomy 13 (T13), or triploidy.
Data regarding study design, patient characteristics, interventions, outcomes, quality, and applicability were extracted.
Data on maternal characteristics, interventions and outcomes came from the Birthplace national prospective cohort study.
There were no consistent subgroup differences between other patient characteristics, interventions, and primary care providers.
Information was extracted relating to the study design, population characteristics, interventions, and the outcomes of interest at 12 weeks.
The same two investigators reviewed the full texts of eligible studies independently and collected data for study and patient characteristics, interventions and items for bias risk assessing.
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Two reviewers independently extracted data on study characteristics, patient characteristics, intervention, and outcome measure.
Trials appropriate for inclusion had to be randomized controlled trials fulfilling certain criteria concerning study design, participants' characteristics, intervention characteristics, and principal outcome measures.
Information on study design, sample size, participant characteristics, intervention, follow-up duration, and treatment outcomes was independently abstracted using a standardized protocol.
Domains include organizational characteristics, individual and team characteristics, intervention characteristics, and process of implementation.
DATA EXTRACTION:Study design, patient characteristics, intervention approaches, follow-up times, and outcomes were abstracted.
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