Summary characteristics for the models simulated are listed, including the minor allele frequency simulated, the heritability of the simulated model, and the genetic model used.
Because there were no female presidents in the data set, the AI was unable to deduce that gender was not a relevant characteristic for the model.
The differences in SD scores for all fetal growth characteristics for the unadjusted model, the adjusted model, and for the five imputation models are shown in Supplement I. Supplement II and III show the individual data points of exposed and non-exposed women for fetal weight and fetal head circumference in the second trimester, third trimester and at birth.
The internal validation data set was used to evaluate the performance characteristics of the model for five quintiles of risk scores including population attributable risk, sensitivity and specificity.
A receiver operating characteristics analysis for the model yielded an area under curve of 0.890 955% confidence interval, CI 0.845 0.934), which denotes an excellent discriminatory capability.
Home and occupant characteristics needed for the model but not available in these data sets were assigned based on independently determined relationships between these unspecified characteristics and data that are included in the databases or from other available data sources.
We selected patient mix and admission characteristics for the second model based on the bivariate analyses with study group and the variable of interest in the model (age, gender and all admission characteristics that could potentially have caused the outcome such as LOS, urgent admission, intensive/intermediate care stay and surgery during admission).
In the test sample, the area under the receiver operating characteristic curve for the model predictions was 0.74, compared with 0.80 in the training sample, and model predictions agreed well with observed prevalences of return to work.
The area under the receiver-operator characteristic curve for the model was 0.94.
Special characteristics for the mice models have been published previously [15, 18, 19].
