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However, the PB1 protein was found to contain only a single characteristic site.
By isolating and concatenating characteristic site residues, we defined adaptation signatures, which summarize the adaptive potential of specific isolates.
This result was by no means expected, and it strongly supports the utility of our characteristic site catalogue as an assessment tool.
Characteristic sites and their characteristic variants (mutations) were selected based on four empirical criteria, whose rationale is detailed in [11], and summarized as follows: At a characteristic site, MI≥0.4 (found to be the MI threshold below which avian and human sequences converge to the same consensus amino acids).
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Its most characteristic sites are in the area of the great salt lakes of southern Tunisia, the type site being Jabal al-Maqtaʿ (El-Mekta), near Gafsa (Capsa, or Qafṣah).
Characteristic sites, e.g. supplying cultural services, are displayed and relationships with the natural environment are explained using linked on-screen text.
Awareness of the characteristic sites of tumour spread is important to allow accurate identification of all sites of disease.
Knowledge of the characteristic sites of spread in such cancers is felt to be essential for the radiologist when reporting staging and restaging CT scans.
Observed differences in gene expression between the two fibroblasts types in response to Wnt are likely to due to the fact that fibroblasts from different anatomic sites are distinct differentiated cell types with programmed epigenetic differences and characteristic site-specific gene expression patterns [19].
All accepted characteristic sites had less than 5.2% avian variants (average at all characteristic sites was 0.71%).
Our analysis produced a catalogue of 68 characteristic sites that met selection criteria (Table 4).
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