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Characteristic networks, consisting of the union of solutions of several unique networks, are interpolated on a rectangular grid covering the whole problem domain.
Once cultured on Matrigel, however, they formed characteristic networks of tube-like structures.
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Moreover, Moeller et al. have demonstrated that microstimulation in the face-selective patches in the ventral stream activates a characteristic network of cortical and subcortical areas [32].
Thus controlling for k does not affect the detection of characteristic network properties of disease genes.
2) Can we identify characteristic network properties that distinguish disease from nondisease genes?
We therefore believe that incorporating information about the evolutionary age of each gene into the network analysis is essential for revealing characteristic network properties of genes.
For this characteristic network topology we introduced logical interaction hypergraphs (LIHs) [ 13] as a special representation of Boolean networks, which is well suited to formalize, visualize and analyse logical models of signal transduction networks.
As expected, there is no identifiable pattern in the case of shared characteristics networks (figure 5).
The combination of all possible interactions generates 7 different networks, referred to as shared characteristics networks in the rest of the manuscript.
The preferential attachment network as well as the shared characteristics networks resulted in small average path distances, comparable to the distances in the corresponding random graphs but, global clustering coefficients much higher than their corresponding random networks (Table 1).
These included: organizational culture, its structural characteristics, networks and communication, implementation climate and readiness, presence of supportive leadership, and provider attitudes and beliefs.
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