All of the patients were asked about the presence and characteristics (localisation, quality and intensity) of morning headache (headache upon waking in the morning) by MM or KS during a face-to-face interview.
The baseline questionnaire is used to measure different patient characteristics (age, gender, race, social status, Body Mass Index (BMI)), disease related characteristics (localisation of symptoms, duration of symptoms, family history) and co-morbidities.
However, because of its homology to follistatin and its characteristic nuclear localisation, it is a candidate gene for the RNASE5 pathway [ 42].
Despite a lack of unequivocally volcanic characteristics, the localisation and rounded, lobate shape of these plains strongly support volcanic origins.
Therefore, standardizing CT reports to include nodule characteristics (size, localisation, spiculation, calcification, and mediastinal node) would be useful.
It has been shown that different protein isoforms generated by alternative splicing can have diverse functional properties, such as binding characteristics, subcellular localisation or enzymatic activity [ 6] or have altered structural properties [ 6] or tissue specificity [ 3].
In our GluLKB1KO model, lineage-tracing studies demonstrated that loss of LKB1 from proglucagon-expressing precursors leads to increased numbers of cells within the duodenum (and more abundantly in the polyps) with mesenchymal characteristics and localisation (Fig. 4 and supplementary material Fig. S1).
Immunoreactivity had characteristic cell membrane localisation and was restricted to tumour cells, whereas surrounding tissue was negative for GD2.
Irga6 transfected into unstimulated mouse L929 fibroblasts accumulated in cytoplasmic aggregates (Martens et al, 2004), instead of the smooth ER localisation characteristic of the endogenous, IFN-induced Irga6 protein.
