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Despite this low sequence identity, possum IL-2 still possessed the characteristic hallmarks of mammalian IL-2, such as a predicted signal peptide and conserved family motifs.
Since the definition of these characteristic hallmarks in 20011, and the subsequent genomic revolution that has occurred in the field of cancer biology, multiple groups have proposed gene expression signatures as biomarkers of these phenotypic hallmarks3,4.
These mice spontaneously developed characteristic hallmarks of human psoriasis, including extensive acanthosis, increases in dermal CD4+ T cells, infiltrating epidermal CD8+ T cells, dermal dendritic cells and macrophages, and increased expression of cytokines and chemokines associated with psoriasis, including interferon-γ, tumor necrosis factor-α, and interleukins 1α, 6, 12, 22, 23, and 17.
Despite these superficial convergences, they all show the characteristic hallmarks of giraffids in their teeth, skulls, and skeletons.
Pratchett is known for a distinctive writing style that includes a number of characteristic hallmarks.
Hence, we analyzed whether acadesine might induce characteristic hallmarks of autophagy.
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There is variable hypertrophy of smooth muscle within the corium primarily in a hamartomatous context in that the smooth muscle is unassociated with any hair follicles another characteristic hallmark of the Becker's nevus.
As exploring this mechanism is our fundamental goal, we do not consider the detailed physiological mechanisms which underlie the 2- 4 Hz spike-wave dynamics that are the characteristic hallmark of absence seizures observed in EEG.
We further evaluated the mice for evidence of helper CD4 T cell loss which is a characteristic hallmark of HIV-1 infection.
Basic pentacysteine refers to five highly conserved Cysteine residues in the basic zinc finger-like DNA-binding domain, the characteristic hallmark of the plant specific BBR/BPC protein family [17], [18].
Loss of contact-inhibition is one characteristic hallmark in tumourigenesis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com