Mutagenic saturation of the A. thaliana gene complement has yet to be achieved, since 6,004 loci still do not have a characterised T-DNA insertion event.
A series of 21 phenotypically characterised T-cell lymphomas histologically defined as lymphocytic, lymphoblastic, immunoblastic, AILD type, pleomorphic, T-zone and Lennert's T-cell lymphoma, were investigated for T-cell receptor (TcR) and immunoglobulin (Ig) gene rearrangements.
18 We aimed to comprehensively characterise T cell immune responses against HCV genotype-3 and to compare T cell specificity between HCV genotype-1 and genotype-3.
To characterise T-cell autoreactivity towards citrullinated self-epitopes, we profiled responses of SE+ healthy controls and RA patients to citrullinated and unmodified epitopes of four autoantigens.
Alveolar RMS is characterised by t(2 13)(q35;q14) or t(1 13)(q36;q14) translocations, which fuse the 5′ portion of the paired box proteins 3 or 7 (PAX3 or PAX7), including an intact DNA-binding domain, to the transactivation domain of a forkhead transcription factor (FOXO1), creating novel PAX3-FOXO1 (t(2 13)(q35;q14)) or PAX7-FOXO1 (t(1 13)(q36;q14)) fusion proteins (reviewed in Wang (2012)).
Best characterised for T cells, differentiation into T helper 1 (Th2), Th17 Th17 and regulatory T cells (Treg) is governed by underlying changes in DNA/histone methylation and/or histone acetylation (as recently reviewed by Janson et al. 2009).
This event leads to T helper 1 (Th1) activation of T cells, an adaptative immune response characterised by T cells production of interferon- γ (IFN- γ), and implicated in cancer growth control (Dhodapkar et al, 2002).
Although the ligands for γδ T cells are not well characterised, γδ T cells may also be selected on cognate self-peptide 1.
We have characterised the T cell compartment in septic shock and assess its clinical implications.
Acute promyelocytic leukaemia (APML) is a condition classically characterised by t(15 17) (q21, q21), with disseminated intravascular coagulopathy (DIC) being a major cause of death.
