To investigate UPS function in a well-characterised mouse model of HD, we have crossed R6/2 HD mice with transgenic UPS reporter mice expressing the GFPu construct.
To investigate the effect of hypoxia on the HIF pathway in the retina we used a well-characterised mouse model of oxygen-induced retinopathy (OIR) [21].
Results In this study, the authors used a well-characterised mouse model of type 2 diabetes to determine how the diabetic environment affects the differential activation (or polarisation) of myeloid progenitors.
This has been well characterised in mouse models of SMA, where there appears to be high levels of NMJ loss in some muscles and very low levels of NMJ loss in others [ 39, 40, 33].
We have now developed and characterised a new syngeneic mouse model of metastatic breast cancer in C57BL/6 mice.
By characterising the transgenic arcAβ mouse model of AD which presents a strong vascular pathology at early, mid and late disease stages we investigated what processes could possibly instigate the vascular and metabolic impairments early on in the disease and which mechanisms aggravate the vascular pathology at later stages in this AD mouse model.
The validity of autophagy modulation as a therapeutic strategy has been shown in a mouse model of Ulrich myopathy characterised by defective autophagy and accumulation of dysfunctional organelles.
These were characterised by immunostaining, patch-clamp electrophysiology, insulin secretion, transcriptome analysis and transplantation into a streptozotocin (STZ -induced mouSTZ -induceddiabetes.
The UN-KPC-961 cell line was derived and characterised in our laboratory (Torres et al, 2013) from a primary tumour developing in KPC (LSL- KrasG12D/+ Tr p53R172H/+;Pdx-1- Cre) genetically engineered mouse model of PC (Hingorani et al, 2005).
"Using this mouse model of COPD, VA researchers will test potential new treatments for the disease".
In this study, we used MS-based global tyrosine phosphorylation profiling to characterise three commonly used mouse models of breast cancer, which revealed distinct differences between these models and features conserved with subtypes of the human disease.
