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Developing NGF-dependent sympathetic neurons are a very well characterised model of neuronal apoptosis.
In rodents and other mammals, sustained activation of the β-adrenergic system by chronic administration of iso is a classical and well characterised model of left ventricular hypertrophy (LVH) independent of blood pressure [12].
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As with D. magna, zebrafish (Danio rerio) are a well characterised model species, especially in the fields of molecular genetics and developmental biology (Kimmel et al., 1995; Langheinrich, 2003).
We have now used this well-characterised model of membrane trafficking to quantitatively test for the first time, using flow cytometry, the impact of clathrin knockout on cell cycle progression in a suspension cell-line.
The human breast cancer cell line MDA-MB231 is a well-characterised model of metastasis invasion in vivo.
The spontaneously hypertensive rat (SHR) is a well-characterised model of this disorder and has been shown to exhibit dopamine dysregulation, one of the hypothesised causes of ADHD.
Methylcholanthrene-induced sarcoma-bearing mice (MCG 101), which is a well-characterised model of cancer-induced anorexia-cachexia (Gelin et al, 1991), were used in the present study.
In vitro a well-characterised model of human colon cancer cell lines exists and reflects the adenoma-carcinoma progression to facilitate research.
Lipopolysaccharide (LPS)- endotoxin from gram-negative bacteria elicits a strong immune response and intraperitoneal injection of LPS is a well-characterised model of systemic inflammation in rodents.
HUVEC were selected as they are a well-characterised model of inflammation [25,26] that have been previously used in leukocyte adhesion assays [27,28].
Ten key enzymes of energy metabolism were determined in vitro in myocardial tissue (removed post mortem) of septic and non-septic (sham) baboons under systemic anaesthesia, a standardised and hemodynamically well-characterised model of E coli sepsis.
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