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In a previous study, two electrophysiological patterns for torsadogenic drugs were characterised in the model of isolated canine Purkinje fibres from their respective effects on action potential.
In recent years resistance to most of these aphid species has been identified and characterised in the model legume Medicago truncatula Gaertn [ 21- 24] with the exception of CPA resistance.
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The UPRmt system has been best characterised in the nematode worm model Caenorhabditis elegans, but there is substantial work supporting the existence of this system in mammalian cells.
In the following experiments, the immunostimulatory and immunosuppressive properties of temsirolimus were characterised in our model.
To better understand these opposing functions, the immune effects of mTOR inhibition were characterised in our model.
The metabolic pathway leading to their production has been well characterised in some model plants [2].
Finally, Dixon et al. did not specify how disease onset and progression was characterised in their model [35].
The coreceptor switch is a phenomenological observation for which a corresponding process has to be characterised in our model.
However, the effect of high-risk HPV on global gene expression has been studied and characterised in several model systems on different microarray platforms (Chang and Laimins, 2000; Nees et al, 2001; Alazawi et al, 2002; Vernell et al, 2003; Garner-Hamrick et al, 2004; Loercher et al, 2004; Santin et al, 2005).
This builds on so-called 'intrinsic tumour suppression', a concept that has been extensively characterised in model systems, in particular in studies on the MYC oncogene (Lowe et al, 2004).
The majority of fish miRNAs have been characterised in model species (360 for Danio rerio, 131 for Fugu rubripes and 132 for Tetraodon nigroviridis), with the exception of rainbow trout [ 34].
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