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A phenotypically well characterised highly prevalent spontaneous canine model for rare human cancers opens the possibility for in vivo research with a short interval between generations.
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Whether the subject is cancer genomics or climate change or education policy, society increasingly expects science to do something beyond its remit, that is, to characterise highly complex systems in terms of unambiguous cause-effect relations that are useful for engineering or decision-making.Uncertainty is an inescapable part of life.
This instrumentation is often used in metabolomics to characterise highly complex samples.
We have previously demonstrated that overexpression of NG2 in NG2 negative tumour cells produced highly angiogenic tumours characterised by highly tortuous and leaky vasculature [ 5, 9].
In a further study by the GOG (Zaino et al, 2010), advanced stage mucinous adenocarcinoma of the ovary is being characterised as highly lethal with highly significantly lower OS rates compared with women with serous carcinoma (14 vs 42 months; P<0.001).
The MT-1/2 isoforms (exemplified by the highly expressed member, MT-2A) are characterised as highly neuroprotective proteins essential for brain repair [13] [15].
One of the most important groups of PRR is the Toll-like receptor (TLR) family of type I transmembrane proteins, characterised by highly divergent, leucine-rich extracellular domains and highly conserved Toll-IL-1R (TIR) cytoplasmic domains.
Our analyses further highlight the unusual nature of the peridinin-containing dinoflagellate chloroplast genome, which is characterised by highly reduced gene content, atypical genomic organisation and highly divergent gene sequences.
The automotive vehicle is a complex system characterised by highly nonlinear longitudinal and lateral coupled dynamics.
A large number of parameters influence the process, which is characterised by highly non-linear and stochastic phenomena.
A substantial portion of the service life of aerospace structures is characterised by highly variable loading conditions.
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