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One of the best characterised examples of a paralogon includes the genes around the MHC complex on human chromosome 6, with homologues on chromosomes 1, 9, 5, 15 and 19 [ 19, 20] (figure 1).
The most characterised examples of epigenetic mechanisms to date in mammalian cells include DNA methylation of cytosine and post-translational modifications to the core histone proteins of the nucleosome (reviewed in [ 1]), though other epigenetic mechanisms are known to exist.
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To our knowledge, this represents the first structurally characterised example of secondary amine coordination to an organocopper(I) centre.
A well characterised example of allosteric regulation of SLiM-mediated interactions involves ligand-induced activation of the Wiskott-Aldrich syndrome protein (WAS), where binding of Cdc42 relieves a motif-mediated auto-inhibitory interaction in WAS, resulting in activation of the protein [ 102].
The extent to which these aggregates represent biologically meaningful structures remains unclear; however there are well characterised examples in which the assembly of higher-order structures regulates flux through specific metabolic pathways.
Halometallate anions of GeII are more common than those of GeIV, with well-characterised examples of [GeX3]− known for X=Cl and Br.
The other well-characterised examples of zinc-finger proteins involved in tumorigenesis include those encoded by the genes of GLI, KS1, Evi9 and BCL11 subfamilies.
Currently, few proteins resulting from recent de novo gene birth have been functionally characterised, and examples of motif-containing novel proteins are even rarer.
In other cases the category may be incompletely characterised: there will be examples of items falling within the category but no general characterisation of it (see Levenbook 2000, 201 11).
The group's share price is now down more than 40% since the start of December and the retailer's demotion from the premier league of UK listed companies was on Tuesday characterised as an example of the punishment investors can mete out to large companies that appear not to treat their workers fairly.
If this occurs there are opportunities for biotechnology to be characterised as an example of Post Normal science from a scientific as well as an technological epistemology.
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