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These seminal studies have systematically identified a subgroup of breast tumours that are characterised by the expression of genes normally expressed in basal/myoepithelial cells of normal breast, including high-molecular-weight cytokeratins (CKs) and P-cadherin [ 6- 10].
Because LAPC-4 cells are characterised by the expression of the wild-type AR, they are assumed to have a homeostatic AR signalling.
They are characterised by the expression of both stromal and haematopoietic markers.
These cells are characterised by the expression of the transcription factor RORγt and the production of the cytokines IL-17, IL-22, IL-6 and tumor necrosis factor-α (TNF-α).
However, the early inflammatory environment is not only characterised by the expression of inflammatory cytokines.
T helper 1 immune response is characterised by the expression of the transcription factor T-bet in CD4 T lymphocytes.
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We previously reported that the combination of TGFβ and CCN2 induce a gene expression profile characterised by the differential expression of a unique subset of genes in human mesangial cells [ 13].
A prominent candidate is a population of naturally occurring regulatory T cells characterised by the surface expression of CD4+ and nuclear expression of the transcription factor Foxp3 (Tregs).
Group 2 was characterised by the same expression pattern, but showed, unlike group 3, low ALCAM expression levels.
Our results show that most (eight out of nine) synovial sarcomas clustered as a single group based on their gene expression portrait and that this cluster was characterised by the raised expression of a set of 48 genes.
In summary, the liver of morbidly obese patients without histological abnormalities had a low-grade inflammation characterised by the elevated expression of inflammatory markers and could be more responsive to endotoxin and saturated fatty acids due to the elevated expression of the Toll-like receptors.
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