A process characterised as a "second-chance scramble" was mired in further problems when those trying to get hold of unsold leftovers for the least popular sports ran into a jammed website on Friday morning.
But as paradigms shift, there is not merely an excitement about the extended possibilities of the new form, but also a series of reactions – I had them myself – which might loosely be characterised as, at first, angry (I hate those ebooks), then defensive (alas, they are quite useful), then nostalgic (I rather miss real books), and finally accepting (couldn't live without my e-reader!).
In the CNS, TIMP-1 was first characterised as a candidate plasticity gene induced by seizures and by stimuli leading to long term potentiation (LTP) [3], a form of synaptic plasticity considered as a cellular substrate of learning and memory.
This element was first characterised as a cis-acting element involved in salicylic acid responsiveness and systemic acquired resistance in wild cabbage (Brassica oleracea) [ 41].
The Coxsackie and adenovirus receptor (CAR) was first characterised as a viral attachment site on the surface of epithelial cells and was later identified as an integral component of the tight junction complex (Coyne and Bergelson, 2005).
SLPI (59-fold) was first characterised as a protease inhibitor but is now recognised as having additional properties including antimicrobial and immunomodulatory activities associated with the innate immune response.
First characterised as a posterior patterning gene acting early in the segmentation gene cascade in Drosophila (in which the gene is called caudal) [ 41], Cdx has subsequently been studied in many other arthropods [ 42- 51].
The opposition is sometimes characterised as liberal.
Intriguingly, VEGF itself was first identified and characterised as a potent stimulator of endothelial permeability and elevated circulating levels of VEGF seem to correlate with severity of sepsis and septic shock [ 19- 21].
Third Age has been characterised as a period of life after retirement, in which one is free from many social roles, and able to explore areas of personal fulfilment.
