Sentence examples for characterisation of pathways from inspiring English sources

Considerable progress has been made in the characterisation of pathways and enzymes for the biosynthesis and degradation of anandamide and 2-arachidonoylglycerol, the two best-known endocannabinoids, as well as of endocannabinoid-related molecules, such as the N-acylethanolamines, which, as in the case of N-palmitoylethanolamine and N-oleoylethanolamine, may interact with other receptor types.

These include, for example, molecular subclassification of breast cancer, characterisation of pathways important in breast cancer aetiology and progression of premalignant lesions, and prognostication of natural history or prediction of benefit to specific therapies.

Given the small number of patients, these observations are hypothesis-generating only, and more complete characterisation of pathway activity in future clinical trials will be needed to fully explore biomarkers of response.

In conclusion, our extensive molecular characterisation of EGFR pathways may explain the failure of TKI administration and may open up the possibility of developing new targeted therapies.

Ongoing studies are focused on further characterisation of these pathways and the functional significance of the overexpressed genes in specimens from doxazosin-treated patients.

Not long after the initial characterisation of these pathways, the functional significance of the DDR activation was revealed by genetic studies indicating that ATM and Chk2 were critical tumour suppressors downstream of oncogenes including H-RasV12, Mos, Cdc6, and cyclin E (Bartkova et al, 2006; Di Micco et al, 2006).

To enable more comprehensive characterisation of MAPK7-pathway signaling, we sought to identify cellular pharmacodynamic biomarkers using a reverse-phase protein array (RPPA) platform.

Previous characterisation of the oncogenic pathways required to transform these cells showed that, as for other cell types, expression of SV40 Large T antigen (LT), which inactivates the p53 and Rb pathways, permits the cells to proliferate mitogen-independently but they retain a strict requirement for attachment and exhibit contact inhibition of proliferation.

Characterisation of the individual pathways of mitotic catastrophe will improve our understanding of cancer biology and uncover novel therapeutic targets.

Characterisation of the signalling pathways utilised by RANKL-RANK is aided by their similarities to other TNF superfamily members.

Genome mining orphan NRPS/PKS gene clusters from the Subsection V cyanobacteria has uncovered novel biosynthetic gene clusters with unique genes, however, screening for the products themselves or characterisation of the enzymatic pathways is necessary to determine if the gene clusters are functional, or remnants of evolution.