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Several factors were identified that could explain contradictory findings (small sample size, selection bias, insufficient characterisation of exposure, lack of consideration of confounders) but their actual impact could not be conclusively assessed with the published information.
The key research questions in measurement and quantification research are: The basic quantity for the characterisation of exposure is the absorbed dose, so whereever possible dose measurements or calculations/calibrations should be stated in terms of absorbed dose (1, 2, 3).
The characterisation of exposure to workplace factors is however, frequently constrained by the multiple physical demands of many workplace tasks, whose inter-relationships are not well understood [ 26, 35, 36].
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The design aims to circumvent important limitations of previous studies into IEI-EMF, which can be summarised as biased recall of health outcomes, poor characterisation of individual exposure to EMF and experimental exposure conditions that substantially differ from the real-life situation (ie, low ecological validity).
Risk characterisation of human exposure to chemicals requires information on the intrinsic toxic (hazardous) properties of the chemical, dose response of effects for the critical endpoints and exposure of the population.
These detailed data allowed both precise characterisation of the exposure of interest and adequate control of confounders.
The characterisation of field-based exposure conditions concerning the biotic or abiotic resuspension of sediments and the rate of attenuation of released contaminants through dilution or readsorption may enable laboratory-based bioassay designs to be adapted to better match those of the assessed environment.
The characterisation of some candidate exposure variables could be expressed in multiple forms (e.g. continuous, categorical, dichotomous, as well as individual versus composite variables).
Future studies should prioritise the characterisation of the timing of exposure in relation to the birth.
Finally, the directional characterisations of these exposures were determined with an alternative method that was based on climatic data from the Chilean stations.
Uses of a substance that result in a risk characterisation ratio (RCR - quotient of exposure level and effect level) below 1 are considered to be safe, while RCR��> 1 will require additional measures to be prescribed in the exposure scenario in order to define an acceptable risk.
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