Exact(1)
Unsupervised hierarchical clustering of the 769 CNA-affected genes (see Additional file 9: Table S6) against the 40 arbitrarily selected primary RCCs (see chapter "Gene delineation") showed rather diffuse RCC clusters indicating at first no direct linkage to the three RCC signatures.
Similar(59)
This chapter describes gene switching, a simple but powerful method that employs antisense technology to specifically shut down an endogenous gene and replace it with an engineered construct transfected into the cells under study.
The chapter describes gene expression, cell metabolism, cofactor availability, oxygen transfer, and catalyst stability as possible targets for improving catalyst efficiency.
Darwin turns up again in the chapter on genes, worrying that "the reckless, degraded and often vicious members of society" tended to increase at a quicker rate that the virtuous and provident, and this provides an opening for a short history of eugenics, beginning with his cousin Francis Galton and embracing Trofim Lysenko as well as Gregor Mendel and William Bateson.
Chapter 11, "Genes and Disease", is dedicated to the genetic basis of diseases.
At first sight the chapters on gene therapy and genetically modified vaccines were equally disappointing to that on TNF particularly so given the amount of hype there has been over the area.
This chapter discusses the gene library synthesis by structure-based combinatorial protein engineering (SCOPE).
This chapter reviews some gene transfer strategies and the potential of the vascular-targeted AAVP vector for enhancing the effectiveness of existing systemic gene delivery and genetic-imaging technologies.
This chapter also addresses gene therapy and ligand-based approaches to targeting the vasculature.
The authors cover a broad field, describing the molecular portrait of breast cancer using microarray analysis (also reviewed in detail in chapter 8) of gene and microRNA expression and the difficulties implementing such techniques into clinical practice, recently emphasised by Weigelt et al (2010).
In one chapter, Trace: On Genes and Crime, Steinberg investigates the search for a "criminal gene".
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